Steven Bergwijn had a dream debut as he scored for Tottenham in a 2-0 win over Man City.
The £25million arrival from PSV Eindhoven gave Spurs a 63rd-minute lead with their first shot on goal, before Heung-min Son sealed the points for Jose Mourinho.
Steven Bergwijn had a debut to remember
City will be wondering how they did not score with Sergio Aguero hitting a post, Ilkay Gundogan having a penalty saved by Hugo Lloris and Kevin De Bruyne’s cross being diverted on to the crossbar.
The game turned when Oleksandr Zinchenko was shown a second yellow card for a foul on Harry Winks on the hour mark.
The result saw Tottenham rise to fifth in the table, while Man City dropped more points in their so-far disappointing title reign.
Liverpool equalled City’s record of 20 consecutive home victories in the Premier League with a straightforward 4-0 victory over Southampton at Anfield.
Second-half goals from Alex Oxlade-Chamberlain, Jordan Henderson and two from Mohamed Salah moved the Reds 22 points clear at the top of the table as their inevitable march towards the title continues.
Salah was at the double for Liverpool
Manchester United and Wolves played out an uninspiring 0-0 draw at Old Trafford in the late kick-off.
Bruno Fernandes made his debut for the Red Devils and looked promising in a game that will be quickly forgotten.
There was high drama elsewhere in the top-flight as Everton and Brighton both staged remarkable comebacks from two goals down.
Watford were seemingly cruising when goals from Adam Masina and Roberto Pereyra put them two goals up on 42 minutes – but their lead was cancelled out before half-time.
After Antonio Rudiger scored twice for Chelsea in their 2-2 draw with Leicester earlier, fellow defender Yerry Mina did the same with two goals in first-half injury time.
Defenders scored for fun on Saturday
Fabian Delph saw red for a second yellow but that didn’t stop Theo Walcott scoring a 90th-minute winner for the Toffees to complete a stunning 3-2 victory.
Meanwhile, Brighton fought back from 3-1 down to draw 3-3 at West Ham thanks to a controversial VAR-awarded equaliser from Glenn Murray.
In another big match at the bottom, ten-man Bournemouth held on to secure a priceless 2-1 victory over fellow relegation battlers Aston Villa, while Norwich earned a 0-0 draw at Newcastle.
A Vicente Guaita own-goal was enough to give Sheffield United a 1-0 victory at Selhurst Park.
Elsewhere, Arsenal were held to a goalless at Burnley as Jay Rodriguez hit the crossbar late on.
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Premier League results
Leicester 2-2 Chelsea
Bournemouth 2-1 Aston Villa
Crystal Palace 0-1 Sheffield United
Liverpool 4-0 Southampton
Newcastle 0-0 Norwich
Watford 2-3 Everton
West Ham 3-3 Brighton
Manchester United 0-0 Wolves
Burnley 0-0 Arsenal
Tottenham 2-0 Man City