Liverpool will be looking to take full advantage of a depleted Tottenham team when they travel to north London on Saturday.
The Reds lead second-placed Leicester by 13 points and are unbeaten in the Premier League this season.
Sadio Mane and Mohamed Salah are aiding Liverpool’s title push
Jurgen Klopps side will be favourites to keep their impressive run going against a Tottenham side without influential duo Harry Kane (hamstring) and Moussa Sissoko (knee).
Both players sustained injuries in Tottenhams 1-0 defeat at Southampton on New Year’s Day.
And with Spurs still without captain Hugo Lloris, who is recovering from a serious elbow injury, Sadio Mane and co will fancy their chances of getting on the score sheet.
In a game which is LIVE on talkSPORT, we look at how both sides could line up.
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Tottenham
Lloris is on the verge of returning to training after suffering a nasty elbow injury in a 3-0 defeat to Brighton in October.
But the game comes too soon for the Frenchman, so second-choice stopper Paulo Gazzaniga will continue in goal.
Defence, surprisingly, has been a problem for Mourinho, whose teams are renowned for being hard to beat.
Spurs have kept just one clean sheet in Mourinho’s first 12 games in charge.
Harry Kane is injured with a hamstring issue
The Portuguese could set up in a back-five to frustrate Liverpool with Toby Alderweireld, Jan Vertonghen and Davinson Sanchez in the middle, with Serge Aurier and Ryan Sessegnon deployed as wing-backs.
In a midfield three, with no Tanguy Ndombele (hip), Christian Eriksen is likely to partner Eric Dier with Dele Alli in a more advanced role.
Harry Winks is a doubt after being taken off in last weekend’s 1-1 FA Cup draw at Middlesbrough.
Heung-Min Son played as a makeshift striker when Kane suffered an ankle injury last season, and he looks set to do it once more, with support from Lucas Moura.
The pace of Son and Moura could cause Liverpool problems.
How Tottenham could look against Liverpool
Liverpool
Alisson is expected to come back in goal, despite Adrian impressing in Liverpools 1-0 FA Cup win over Everton last weekend.
Trent Alexander-Arnold and Andy Robertson will be aiming to continue their fine form in the full-back berths, with Joe Gomez and Virgil van Dijk in the heart of the defence.
That back-four has kept three successive clean sheets in the Premier League.
Xherdan Shaqiri returned to first-team training this week after recovering from a muscle injury, but is unlikely to start.
Xherdan Shaqiri is back in contention to play
Alex Oxlade-Chamberlains substitute appearance against Everton could earn him a start alongside Jordan Henderson and Georginio Wijnaldum in midfield.
It remains to be seen whether Naby Keita (groin) will be risked, while James Milner (hamstring) is ruled out.
Mane, Roberto Firmino and Mohamed Salah are likely to feature in a front-three.
How Liverpool could look against Tottenham
Saturday is GameDay on talkSPORT as we bring you THREE live Premier League commentaries across our network, including Tottenham vs Liverpool at 5:30pm